Prevalence of fatigue in Parkinson disease and its clinical correlates

Fabrizio Stocchi, MD, Giovanni Abbruzzese, MD, Roberto Ceravolo, MD, Pietro Cortelli, MD, PhD, Marco D’Amelio, MD, Maria F. De Pandis, MD, PhD, Giovanni Fabbrini, MD, Claudio Pacchetti, MD, Gianni Pezzoli, MD, Alessandro Tessitore, MD, PhD, Margherita Canesi, MD, Claudio Iannacone, Mario Zappia, MD; For the FORTE Study Group. Neurology. Originally published July 15, 2014.

“Approximately one-third of patients with PD have distressing fatigue, which is significantly associated with depression and sleep disorders. The fact that the presence of fatigue worsens patient quality of life supports the need to better diagnose and treat this debilitating symptom.”