Midlife personality and risk of Alzheimer disease and distress: a 38-year follow-up

Lena Johansson, PhD, Xinxin Guo, MD, PhD, Paul R. Duberstein, et al. Neurology. Originally published October 21, 2014.

 

“A higher degree of neuroticism in midlife was associated with increased risk of AD dementia and long-standing distress over 38 years… Extraversion was associated with a lower degree of long-standing distress, but had no impact on AD dementia. When the 2 personality dimensions were combined, high neuroticism/low extraversion showed the highest risk of AD dementia.”